Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair
Status:
Completed
Trial end date:
2019-12-19
Target enrollment:
Participant gender:
Summary
Patients usually experience some level of pain after their hernia repair. To control pain
after the operation, surgeons have many options. One of them is to make some injections of
pain blocker medications into the nerves that are responsible for the sensations the
abdominal wall.This procedure is called TAP block (transversus abdominis place block). These
medications are called local anesthetics, and there is a variety of medications that can be
used. One of such medications is called Exparel® (Liposomal Bupivacaine). Exparel® has the
potential benefit of lasting more hours than regular anesthetics. Although this drug is being
used with increasing frequency, the investigators do not have good quality studies
investigating the benefits of using this medication during a hernia repair, especially when
compared to other types of local anesthetics (Bupivacaine Hydrochloride) or when compared to
not injecting this medication at all. This study aim to investigate if Exparel®, when
injected in the nerves of the abdominal wall during hernia repair can: (1) reduce the dose of
additional opioid medications (morphine and similar) needed to achieve good pain control and
(2) result in lower pain scores. The hypothesis is that Exparel® will result in a 30%
decrease in the total requirements for opioid medications during the first 72 hours after
surgery. Patients will be randomized to receive either Exparel®+Bupivacaine Hydrochloride,
Bupivacaine Hydrochloride or Placebo (normal saline) during the operation through a TAP
block. All patients will receive a patient controlled analgesia device after the operation,
where patients can simply push a button every time they feel pain and the device will
administer a dose of opioid medications. The investigators of the study will record the
necessary amount of opioids used by the patients to achieve good pain control and also record
pain scores several times during hospital stay.