Overview

Exercise-induced Ischemia and the Influence of Pain Modulation in a Nerve Growth Factor (NGF) Model

Status:
Unknown status
Trial end date:
2019-06-30
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to investigate responses of pain and the maintenance of mechanical muscle hypersensitivity following an acute exercise-induced ischemic condition repeated over time in a prolonged NGF-sensitized muscle. Additionally, the influence of the pain modulating system on prolonged NGF muscle hypersensitivity caused by peripheral mechanisms and central mechanisms will also be investigated.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Aalborg University
Treatments:
Mitogens
Criteria
Inclusion Criteria:

- Healthy and pain free volunteers

Exclusion Criteria:

- Pregnancy

- Drug addiction defined as the use of cannabis, opioids or other drugs

- Previous neurologic, mental illnesses, or psychiatric diseases.

- Past history of chronic pain in the musculoskeletal system (muscle, joint, cartilage,
connective tissue)

- Participation in other pain trials throughout the study period

- Lack of ability to cooperate

- Taking any analgesic 24 hours before the injections

- Performing any strenuous leg exercise through out the study period causing sore
muscles