Exercise, Statins, and the Metabolic Syndrome

• Status: Completed
• Trial end date: 2011-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Here we tested if statins or exercise plus statins had a greater capacity to lower metabolic syndrome risk factors in sedentary individuals with at least 2 metabolic syndrome risk factors. We also examined if statins impacted exercise response for mitochondrial content in muscle or aerobic fitness.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Kansas Medical Center
• Collaborators: American Heart Association; University of Missouri-Columbia
• Treatments: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Simvastatin

Criteria

Inclusion Criteria:

• Sedentary metabolic syndrome subjects will be 25-59 y of age

• overweight to Class I or II obese (BMI 25-39 kg/m2) men and women

• 2 of 4 other characteristics of the metabolic syndrome including fasting glucose of 100 to 125 mg/dl; waist circumference greater than 102 cm in men and 88 cm in women, serum triglyceride concentration greater than 150 mg/dl, HDL-C concentrations less than 40 mg/dl in men and 50 mg/dl in women, and blood pressure greater than 130/85 mmHG

• Women must be taking birth control or be postmenopausal.

Exclusion Criteria:

• Diagnosed cardiovascular disease or diabetes or disease

• Symptoms that could alter their ability to perform exercise

• Fasting blood glucose of greater than 126 mg/dl

• Smoking

• Taking any medications or supplements (e.g., statins, fibrates, metformin, thiazolidenediones, anti-hypertensives (ACE-inhibitors and angiotensin blockers) which could affect blood lipids or insulin sensitivity.

• Women who are pregnant or plan to become pregnant during the duration of the study

• Individuals exercising regularly (more than one 30 min session per week)

• Individuals with an orthopedic limitations for walking.

• Report any allergies to the medications (statins, lidocaine)