Exercise Capacity and Quality of Life in Patients With PPH Receiving Short Term Oral L-Citrulline Malate
Status:
Unknown status
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
Due to vasodilatory properties of the NO, one of the therapeutic approaches for IPAH is oral
use of nitric oxide precursors (10). Efficacy of L-arginine is well-documented in the current
literature but there is paucity of data with regard to L-citrulline- malate. Hence, this
study will evaluate therapeutic efficacy of L-citrulline- malate in two categories of
patients with pulmonary hypertension (IPAH, and Eisenmeger syndrome). This randomized
clinical trial utilizes 6-minute walk, pro BNP levels and the echocardiographic indexes an
indicator of functional improvement of the patients.