Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids
Status:
Recruiting
Trial end date:
2032-01-01
Target enrollment:
Participant gender:
Summary
Keloids are a common form of hypertrophic scars that by definition last beyond 6 months and
grow beyond the site of initial injury. Keloids are a common complaint from patients in
dermatology and cause significant functional impairment due to cosmetic disfigurement,
itching and pain. Current treatment modalities include intralesional corticosteroids,
chemotherapeutic agents and laser therapy. Initial reports have demonstrated that Botulinum
toxin type A may be a viable treatment option for keloids that can reduce keloid size and
reduce associated symptoms while having fewer side effects when compared to intralesional
corticosteroid injection, which can cause unnatural blood vessel growth or skin thinning. To
date, no study has carefully examined the efficacy of Botulinum toxin type A in treating
keloids or its mechanistic effects on keloid biology. Our aim in this study is to pursue a
rigorous, randomized control trial to assess the potential use Botulinum toxin type A to
treat keloids. Efficacy will be objectively be mentioned by change in keloid size after
treatment, along with subjective measures of patient satisfaction and symptoms, and finally
physician rated scores. Also, samples from three patients will be analyzed in the laboratory
setting to determine the underlying molecular mechanism behind the effects of Botulinum toxin
type A on keloid biology.
Phase:
Early Phase 1
Details
Lead Sponsor:
University of California, San Diego
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A