Examining the Effect of Different Diuretics on Fluid Retention in Diabetics Treated With Rosiglitazone.

• Status: Completed
• Trial end date: 2004-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Study examining the effect of different diuretics on fluid retention in diabetics treated with rosiglitazone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: GlaxoSmithKline
• Treatments: Diuretics; Furosemide; Hydrochlorothiazide; Rosiglitazone; Spironolactone

Criteria

Inclusion criteria:

• Subjects with type 2 diabetes.

• Stable FPG of >=7.0 and <=12.0mmol/L.

• Subjects had to have been established on SU treatment or SU+MET treatment for at least 2 months.

• Serum creatinine level > 130 micromol/L.

Exclusion criteria:

• Subjects taking > 2 concomitant oral anti-diabetic agents.

• Subjects with HbA1c >=10%.

• Subjects already receiving diuretic medication.

• Subjects unstable or severe angina.

• CHF NYHA class i-iv.

• Subjects with clinically significant hepatic disease.