Examination of the Lipid Metabolism of the Liver After Choline Substitution in Cystic Fibrosis

• Status: Completed
• Trial end date: 2017-02-08
• Target enrollment: 0
• Participant gender: Male

Summary

Pilot study to investigate the effect of choline chloride in cystic fibrosis patients with liver steatosis by comparing their status before and after the intervention

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Tuebingen
• Treatments: Choline

Criteria

Inclusion Criteria:

• Age > 18 years

• male

• Cystic fibrosis is verified

• pancreatic insufficiency

• Decline of plasma phosphatidylcholine and steatosis of the liver

• informed consent is given

Exclusion Criteria:

• cirrhosis of the liver

• Hyperreactivity to choline containing food

• allergic bronchopulmonary aspergillosis or other acute exacerbations of pulmonary infections

• FEV1 < 40%

• smoker

• chronic alcohol consume

• clinically relevant diseases (for example thyroid dysfunction, disturbance of lipid metabolism, renal diseases, significant left or right ventricular functional restriction) which will change the lipid metabolism of the liver

• Implants or other reasons which make magnetic resonance examinations impossible