Overview

Everolimus and Anakinra or Denosumab in Treating Participants With Relapsed or Refractory Advanced Cancers

Status:
Completed
Trial end date:
2021-02-24
Target enrollment:
0
Participant gender:
All
Summary
This phase I trial studies the side effects and best dose of everolimus when given together with anakinra or denosumab in treating participants with cancers that have spread to other places in the body and have come back or aren't responding to treatment. Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Anakinra is designated to block a protein that is involved in tumor development, new blood vessels growing, and the spread of cancer. Monoclonal antibodies, such as denosumab, may interfere with the ability of tumor cells to grow and spread. Giving everolimus and anakinra or denosumab may work better in treating participants with advanced cancers.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
Denosumab
Everolimus
Interleukin 1 Receptor Antagonist Protein
Sirolimus
Criteria
Inclusion Criteria:

- Patients with advanced or metastatic cancers that are refractory to standard therapy,
relapsed after standard therapy, or who have no standard therapy available that
improves survival by at least three months.

- Patients must be >= 3 weeks beyond treatment with a cytotoxic chemotherapy regimen, or
therapeutic radiation, or major surgery. Patients may have received palliative
localized radiation immediately before or during treatment provided that radiation is
not delivered to the only site of disease being treated under this protocol. For
biologic/targeted agents patients must be >= 5 half-lives or >= 3 weeks form the last
dose (whichever comes first).

- Eastern Cooperative Oncology Group (ECOG) performance status =< 2.

- Absolute neutrophil count (ANC) >= 1,000/mL.

- Platelets >= 75,000/mL.

- Creatinine clearance >= 35 ml/min.

- Total bilirubin =< 2 X upper limit of normal (ULN) (exceptions may apply to benign
non-malignant indirect hyperbilirubinemia such as Gilbert syndrome). Exception for
patients with liver metastasis: total bilirubin =< 3 x ULN.

- Alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) and or
aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) =< 5
X ULN. Exception for patients with liver metastasis: ALT (SGPT) =< 8 X ULN.

- Fasting lipid profile: cholesterol =< 350 mg/dL.

- Fasting lipid profile: triglycerides =< 400 mg/dL.

- Corrected calcium >= 8.4 mg/dL.

- Phosphorus >= 2.5 mg/dL for denosumab.

- Oral examination and appropriate preventive dentistry will be performed prior to the
initiation of denosumab therapy.

- Negative tuberculosis quantiferon test for anakinra arm.

- Negative serology for histoplasma, blastomycosis, and Coccidioidomycosis for anakinra
arm.

- Negative serology for active hepatitis B and C for anakinra arm. Patients with
positive serology for hepatitis B might eligible if they are willing to take
lamivudine preventive therapy.

- Women of childbearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry, for
the duration of study participation, and for 30 days after the last dose.

- Patients must be able to understand and be willing to sign a written informed consent
document.

Exclusion Criteria:

- Uncontrolled intercurrent illness, including, but not limited to, uncontrolled
infection, uncontrolled asthma, need for hemodialysis, need for ventilatory support.
Treatment of pre-existing invasive fungal infections must be completed prior to
starting treatment.

- Patients with an active infection.

- Pregnant or lactating women.

- History of hypersensitivity to anakinra.

- History of hypersensitivity to denosumab.

- History of hypersensitivity to everolimus.

- History of hypersensitivity to any component of the formulation.

- Patients unwilling or unable to sign informed consent document.

- Patients treated with TNF antagonists.

- Patients with a history of active systemic fungal infection.

- Patients with liver disease Child Pugh classification B and C.