Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
Status:
Completed
Trial end date:
2019-11-15
Target enrollment:
Participant gender:
Summary
RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth and by blocking some of the blood flow to the tumor. Drugs used in
chemotherapy, such as temozolomide, work in different ways to stop the growth of cancer
cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses
high-energy x-rays to kill tumor cells. Giving everolimus together with temozolomide and
radiation therapy may kill more tumor cells.
PURPOSE: This phase I/II trial is studying the side effects and best dose of everolimus when
given together with temozolomide and radiation therapy in treating patients with newly
diagnosed glioblastoma.