Everolimus MICE-regimen in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
Status:
Unknown status
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as mitoxantrone hydrochloride, cytarabine,
etoposide, and idarubicin, work in different ways to stop the growth of cancer cells, either
by killing the cells or by stopping them from dividing. Everolimus may stop the growth of
cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood
flow to the cancer. Giving everolimus together with combination chemotherapy may kill more
cancer cells.
PURPOSE: This phase I trial is studying the side effects and best dose of everolimus when
given together with mitoxantrone hydrochloride, cytarabine, etoposide, and idarubicin in
treating older patients with newly diagnosed acute myeloid leukemia.