Evaluation the Effect of Exjade on Oxidative Stress in Low Risk Myelodysplastic Syndrome Patients With Iron Over Load
Status:
Completed
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
Certain percentage of MDS patients develop iron overload. Iron is known to participate in
intracellular reactions that generate free radicals, inducing oxidative stress and apoptosis,
which was found to be increased in MDS patients and consequently resulted in ineffective
hematopoiesis. The aim of this study is to evaluate the antioxidant effect of the oral iron
chelator Deferasirox -Exjade in low risk MDS patients with iron over load by evaluating
changes in several oxidative stress parameters Certain percentage of MDS patients develop
iron overload.
Phase:
Phase 4
Details
Lead Sponsor:
Wolfson Medical Center
Collaborators:
Hadassah Medical Organization Sheba Medical Center Soroka University Medical Center Tel-Aviv Sourasky Medical Center