Overview

Evaluation of the Safety, Tolerability and Pharmacokinetics of Intravenous ETX2514 Administered in Healthy Subjects

Status:
Completed
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
This research project is being conducted to look at the safety, tolerability, and pharmacokinetics (PK; how the human body processes a substance) of ETX2514 when given to healthy volunteers intravenously as a single dose, and when given as multiple intravenous doses for up to 8 consecutive days. As it is anticipated that ETX2514 could be used as a treatment for Acinetobacter baumannii (a type of bacteria) infections, this project will also look at whether ETX2514 will interact with the current treatments for these infections when they are administered at the same time.
Phase:
Phase 1
Details
Lead Sponsor:
Entasis Therapeutics
Treatments:
Cilastatin
Imipenem
Sulbactam