Evaluation of the Role of Low Dose Magnesium Sulfate in Anesthesia for Toxic Goiter Resection

• Status: Recruiting
• Trial end date: 2022-01-30
• Target enrollment: 0
• Participant gender: All

Summary

Anesthesia for toxic goiter removal is a challenging because of of hemodynamic instability especially during induction, intubation, manipulations of the gland, after removal of the gland and during emergence. So, hemodynamic stability is required all through the operation and even in the first 12 hours of the postoperative period to protect against complications e.g., hypertension, tachycardia, myocardial ischemia, bleeding and thyrotoxic crisis.Mg sulphate used in blunting pressor response during laryngoscopy and intubation. Also it was used in controlled hypotension technique. Also it was reported in decreasing postoperative nausea, vomiting, shivering and postoperative complications compared to controlled group.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Fayoum University Hospital

Criteria

Inclusion Criteria:

1. patients ASA ǀ &ǁ

2. patients of both sex

3. Aging from 20-70years

4. Pstients with primary or secondary thyrotoxic goiter

Exclusion Criteria:

1. Major hepatic disease

2. renal disease.

3. Cardiac dysfunction e.g. (heart Failure).

4. Uncontrolled hypertension

5. Advanced Ischemic heart diseases.

6. Known allergy to Mg So4.

7. Morbid obesity & pregnancy.

8. History of neuromuscular diseases.

9. cerebrovascular diseases.

10. Diabetic neuropathy.

11. patients receiving magnesium. supplementations.

12. Mental retardation

13. Patients on antiepileptic treatment

14. patients antipsychotics.

15. Hug goiter with retrosternal extension.