Evaluation of the Pharmacokinetic Profile of Tranexamic Acid, After Injection in a Knee Neo-articulation.

• Status: Completed
• Trial end date: 2017-03-14
• Target enrollment: 0
• Participant gender: All

Summary

Evaluate the pharmacokinetic profile of tranexamic acid injected intra-articularly with or without adrenaline, in a population of patients undergoing knee replacement.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brugmann University Hospital
• Treatments: Epinephrine; Epinephryl borate; Racepinephrine; Tranexamic Acid

Criteria

Inclusion Criteria:

• programmed PTG, right or left

• surgery planned within the CHU Brugmann Hospital (Dr Reynders)

• ASA I to ASA III

• Signed informed consent within the patient file

Exclusion Criteria:

• re-do surgery

• urgent or multiple surgery

• ASA IV or higher

• Patients with a BMI superior or equal to 40

• Patient is a Jehovah Witness

• Allergy or contra-indication to tranexamic acid

• Coagulation troubles, defined as: Platelet count < 80 000/mm3 and/or PTT <70% and/or aPTT >45s and/or Fibrinogen <100mg/dL

• Preoperatory renal insufficiency defined as Creatinin > 3mg/dL and/or Dialysis patients.