Evaluation of the Molecular Effects of Metformin on the Endometrium in Patients With Endometrial Cancer
Status:
Completed
Trial end date:
2017-05-28
Target enrollment:
Participant gender:
Summary
The goal of this research study is to learn if metformin can affect endometrial cancer cells
in women who do not have diabetes.
Objectives:
Primary Objectives:
1. To determine the molecular effects of metformin and associated physiologic changes in
insulin/glucose metabolism on the mTOR (mammalian target of rapamycin) signaling pathway in
the endometrium of women with endometrial cancer
Secondary Objectives:
1. To describe the effects of metformin on the histology and proliferation of the
endometrium in women with endometrial cancer.
2. To assess the effect of body mass index on the response to treatment with metformin
3. To assess the effect of insulin resistance on the response to treatment with metformin
4. To determine effects of metformin on the serum, urine and DNA biomarkers of women with
endometrial cancer.