Evaluation of the Influence of Statins and Proton Pump Inhibitors on Clopidogrel Antiplatelet Effects
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
There is conflicting evidence in the literature suggesting that the use of proton pump
inhibitors (PPIs), and/or some statins can interfere with clopidogrel antiplatelet effect and
result in adverse cardiovascular outcomes in patients treated with coronary artery stents and
dual antiplatelet therapy.
The primary aim of the study is to determine the effect of various currently used PPI on
platelet aggregation in patients undergoing percutaneous coronary intervention (PCI) and
treated with dual antiplatelet therapy.
The secondary aim of the study is to evaluate how statins and 2C19*2 polymorphism modulate
the effect of PPI on clopidogrel efficacy.
Phase:
Phase 4
Details
Lead Sponsor:
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec