Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel

• Status: Completed
• Trial end date: 2017-10-02
• Target enrollment: 0
• Participant gender: All

Summary

assess the clinical and laboratory effects of the local and sub gingival application of a 0.8% hyaluronic acid gel (GENGIGEL®) as an adjunct to scaling and root planning (SRP) in chronic moderate to severe periodontitis patients as indicated by expression of Human Beta Definsin-2 (HBD2) in gingival crevicular fluid (GCF).

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Riyadh Colleges of Dentistry and Pharmacy
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• Patients should be systemically healthy with moderate to severe chronic periodontitis of more than 4 mm probing depth in at least two sites in different quadrants.

• Patient should exhibit no known allergies

• Participants should have the ability to attend the hospital regular intervals.

Exclusion Criteria:

• pregnancy

• nursing

• hypertension

• patient with chronic diseases such as diabetes mellitus or rheumatoid arthritis. -Participants should not be under antibiotics and\or had receive any periodontal therapy for the last 6 months.

• Participants should not taking drugs that could affect the state of the gingival tissues.

• Participants must not be undergoing orthodontic therapy, caries free

• Participants must not be using any other supplemental plaque control measures like mouthwashes.

• Participants should not have the habit of taking alcohol, smoking or chewing tobacco and do not suffer from any systemic disease.