Evaluation of the Effect of Self-Assembling Peptide P11-4
Status:
Completed
Trial end date:
2021-10-30
Target enrollment:
Participant gender:
Summary
Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that
results in the phasic demineralization and remineralization of dental hard tissues.
These tissues have poor regeneration capability because of the lack of both regenerative
cells and vascularization.
In the complex caries progression process involving dietary sugars, bacterial metabolism and
demineralization, the collagenous organic matrix becomes exposed and destroyed by resident
and bacterial proteases, allowing the lesion to expand