Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication
Status:
Completed
Trial end date:
2020-04-01
Target enrollment:
Participant gender:
Summary
The current principle of yaws eradication (the Morges strategy) is based on single round mass
drug administration (MDA) of azithromycin (AZI) called total community treatment (TCT)
followed by targeted treatment of active cases every 6 months to detect and treat cases and
contacts called total targeted treatment (TTT). Studies done in Papua New Guinea (PNG) show
that 1 round of MDA will probably not suffice to stop transmission of infection. It may be
preferable to conduct 3 rounds of MDA prior to the switch to TTT because of high coverage
requirements to achieve elimination, particularly of latent cases. The investigators plan to
determine whether 3 rounds of MDA are more effective for reaching yaws elimination. This
research is needed to guide national programmatic implementation and needs to be done as soon
as possible to scale up the program in the country.
The aim of this proposal is to ascertain the number of rounds of MDA with AZI to be included
in an improved strategy towards yaws eradication. The study will be implemented in 38 wards
of New Ireland Province (NIP). The investigators will compare two different distribution
strategies of MDA: (A) strategy with 3 biannual rounds of MDA and (B) a single mass treatment
round of MDA followed by targeted treatment of cases and contacts. The investigators will
also monitor the risk of appearance of antimicrobial resistance in Treponema pertenue.
Phase:
Phase 4
Details
Lead Sponsor:
Lihir Medical Centre
Collaborators:
Barcelona Institute for Global Health Harvard School of Public Health Harvard School of Public Health (HSPH) National Department of Health of Papua New Guinea University of Masarykova World Health Organization
Treatments:
Azithromycin Penicillin G Penicillin G Benzathine Penicillin G Procaine