Evaluation of Treatment for Mycobacterium Avium Complex (MAC) Infection in HIV-Infected Patients
Status:
Completed
Trial end date:
2002-06-01
Target enrollment:
Participant gender:
Summary
To assess the feasibility of using culture and staining techniques to quantify tissue
Mycobacterium avium Complex (MAC) burden in bone marrow. To correlate and compare changes in
MAC bone marrow burden with quantitative MAC blood culture results at baseline and after 4
and 8 weeks of treatment.
MAC is easiest to detect in the blood, although doctors generally believe that MAC in blood
is just "spill-over" from infection of other parts of the body. Traditionally, studies of
potential treatments for MAC focus only on MAC changes in the blood. This study compares MAC
changes in blood to those in bone marrow, which is another tissue where MAC is often found.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)