Evaluation of Trans-mucosal Bio-adhesive Discs of Diclofenac Potassium on the Anesthetic Success and Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial

• Status: Not yet recruiting
• Trial end date: 2022-09-22
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the proposed study is to compare the effect of single dose of Diclofenac Potassium premedication as trans-mucosal bio-adhesive discs versus placebo on the effectiveness of the inferior alveolar nerve block and postoperative pain in patients with symptomatic irreversible pulpitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Diclofenac

Criteria

Inclusion Criteria:

• Patients who are free from any physical or mental handicapping condition with no underlying systemic disease.

• Age between 18-50 years old.

• Males & Females.

• Mandibular permanent molar teeth with:

• Preoperative sharp pain.

• Positive response of pulp tissue to cold pulp tester (ethyl chloride spray ) and electric pulp tester

• Normal periapical radiographic appearance or slight widening in lamina dura using periapical index (PAI) score 1 as normal periapical structures or 2 as small changes in bone structures.

• Patients' acceptance to participate in the trial.

• Patients who can understand pain scale and can sign the informed consent

Exclusion Criteria:

• Medically compromised patients: Pain levels and healing following treatment would be compromised as these patients have shown higher incidence of pain and lower healing rate.

• Pregnant women: Avoid radiation exposure, anesthesia, and medication.

• If analgesics have been administrated by the patient during the past 24 hours preoperatively might alter their pain perception.

• Patients reporting bruxism or clenching: Avoid further pressure on an already inflamed tooth inducing subsequent irritation and inflammation.

• Teeth with necrotic pulp, acute periapical abscess and swelling: Need special treatment steps, it could influence initiation and progression of postoperative pain.

• Greater than grade I mobility or pocket depth greater than 5mm. Need special surgical and/or periodontal therapy.

• No restorability: Hopeless tooth.

• Immature teeth.

• Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.