Evaluation of Propranolol's Effect on Pain and Inflammation.
Status:
Completed
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
Previous studies have shown that the beta-adrenergic system plays a role in processing pain
and the expression of hyperalgesia. Recent studies have investigated the analgesic effects,
and potential anti-hyperalgesic effects (using a model of opioid induced (OIH) hyperalgesia)
of propranolol, a beta adrenergic antagonist. We plan to further investigate the analgesic
effects, and the potential anti inflammatory effects, of propranolol and compare those
effects to alfentanil, an opioid of known effect, and placebo