Evaluation of Preoperative Submucosal Dexamethasone in Third Molar Surgery

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The study composed of sixty patients, each of whom required surgical extraction of a single impacted mandibular third molar under local anaesthesia. The patients were randomly allocated to one of 3 groups of 20 each. The three groups were categorized as Group A (intramuscular dexamethasone), Group B (submucosal dexamethasone) and Group C (control). The objective measurements of facial pain, swelling, and trismus was performed by an independent examiner at baseline (preoperatively), and at days 1, 3, and 7 postoperatively.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Sun Yat-sen University
• Treatments: Acetaminophen; Amoxicillin; BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• ASA (American Society of Anesthesiologists) class I individuals

• Patients age between 18 - 40 years of age,

• Patients presenting with diagnosis of Class II position B impaction (Pell and Gregory classification)

• Patients who consent for regular recall visits

Exclusion Criteria:

• Patients having acute infection at extraction site

• Pregnant or lactating condition

• Smoking or tobacco/areca nut chewing habit

• Any systemic disease or medication therapy that could interfere with wound healing

• Impacted tooth associated with periapical infection or lesion

• Poor oral hygiene

• Patients with immunocompromise conditions