Evaluation of Post-operative Pain and Expression of IL-8 Using Ketolac or Cryoirrigation as a Final Flush in Single Visit Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis and Apical Periodontitis.Randomized Clinical Trial.

• Status: Not yet recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the effect of cryotherapy versus ketorolac tromethamine irrigating solutions used as a final flush in single visit endodontic treatment in mandibular molars, with symptomatic irreversible pulpitis and apical periodontitis on the:

• Intensity of post-operative pain in patients with symptomatic irreversible pulpitis

• Reduction of expression of Interleukin-8 (IL-8) post-instrumentation using ELISA

• The analgesic intake following endodontic treatment for post-operative pain relief.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Ketorolac; Ketorolac Tromethamine

Criteria

Inclusion Criteria:

• - Medically free patients

• Age between 18-40 years old

• Males or females

• Participants able to understand Visual Analogue Scale (the pain chart diary) and sign the informed consent ( Appendix I,II).

• Mandibular permanent molar teeth:

• Diagnosed clinically with symptomatic irreversible pulpitis associated with apical periodontitis.

• Presence of spontaneous pain and sharp pain to cold tester (ethyl-chloride) that lingers after removal of the stimulus compared to the contra-lateral tooth

• Tenderness to percussion with normal periapical radiographic appearance or slight widening of the lamina dura

Exclusion Criteria:

• - Participants allergic to NSAIDS

• Pregnant females

• Participants having significant systemic disorder

• If analgesics or antibiotics have been taken by the patient during the past 24 hours pre-operatively.

• Participants with psychological disturbances

• Participants with bruxism or clenching

• Participants having acute pain in more than one mandibular molar

• Participants with mandibular molar teeth showing:

• Swelling or fistulous tract

• Acute or chronic periapical abscess

• Mobility greater than grade I

• Periodontitis

• Previous endodontic treatment or non-restorability