Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project)
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
The aim of our 2nd sub-project is to clarify if the capsaicin receptor TRPV1 is implicated in
the mechanism of morphine-induced mast cell degranulation. Moreover, we also aim to clarify
if the mechanism of opioid-induced itch relay on the histaminergic pathway by using the
antihistamine (diphenhydramine) to suppress the release of histamine from peripheral mast
cells.