Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria
Status:
Completed
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
Background:
- Malaria is caused by small parasites carried by some mosquitoes. People can get malaria if
an infected mosquito bites them. Malaria destroys red blood cells. Most malaria is mild, but
some children develop severe malaria, which kills about 660,000 people annually. About 9 in
10 who die of malaria are Sub-Saharan African children, most under 5 years old. Scientists
can save many lives if they find out how to prevent or relieve severe malaria.
Objective:
- To know if a common medicine called activated charcoal can reduce severe malaria symptoms.
Eligibility:
- Children 2 to 11 years old with mild malaria who live in Kenieroba, Mali.
Design:
- For the first 2 days and nights, participants will stay in the hospital.
- They will have their medical history taken, and a physical exam.
- Blood will be drawn from a thin tube inserted in their hand or forearm. This will be
done 3 times overall. A drop of blood will be taken from a finger prick 12 times
overall.
- An antimalarial drug will be injected into the tube in the arm 4 times. Each time the
drug is given, participants will drink a small cup of either water or activated
charcoal.
- For the following 3 days, participants will take an antimalarial pill.
- On day 7, participants will visit the hospital. A drop of blood from a finger prick will
be tested for malaria parasites.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)