Evaluation of New Markers to Assess Kidney Function
Status:
Withdrawn
Trial end date:
2011-09-01
Target enrollment:
Participant gender:
Summary
Glomerular filtration rate (GFR) is widely accepted as the best index of kidney function in
health and disease, and accurate values are required for optimal clinical decision making and
in large-scale epidemiologic studies and clinical trials. Current recommended methods for
measuring GFR are expensive, cumbersome to administer and assay and requires urine collection
and administration of radioactive materials. The purpose of this study is to evaluate two
non-radioactive markers (iohexol and gadolinium) compared to urinary clearance of inulin and
iothalamate. The investigators hypothesize that plasma clearance of non-radioactive markers
will be unbiased compared to a gold standard and more precise than currently used urinary
clearance methods.