Evaluation of Methylprednisolone or Ibuprofen on Efficacy of Nerve Blocks With Symptomatic Irreversible Pulpitis

• Status: Recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This prospective, randomized, double-blind study will compare the effect of oral premedication of ibuprofen and methylprednisolone on the anesthetic efficacy of an Inferior Alveolar Nerve Block (IANB) in adult patients with symptomatic irreversible pulpitis.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Walter Reed National Military Medical Center
• Treatments: Anesthetics; Ibuprofen; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria

• 18 years or older

• Has a vital mandibular posterior tooth experiencing pain

• Has a prolonged response to thermal cold testing using Green Endo Ice (1, 1, 1, 2 tetraflouroethane

• Diagnosis of symptomatic irreversible pulpitis

Exclusion Criteria:

• Has taken an analgesic within the past 8 hours

• Allergies or sensitivities to Ibuprofen or Methylprednisolone

• Allergies or sensitivities to local anesthetics or sulfites

• Pregnant or nursing

• Has a history of a serious medical condition preventing routine dental treatment

• Has a medical condition requiring the use of steroid medications

• Active or latent peptic ulcers

• Crohn's Disease

• Ulcerative colitis

• Gastroesophageal reflux

• Systemic fungal infection

• Active herpetic infection

• Asthma

• Open-angle glaucoma

• Cirrhosis