Evaluation of Memantine Versus Placebo on Ischemic Stroke Outcome

• Status: Completed
• Trial end date: 2017-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The researchers aim to investigate the effect of memantine on stroke outcome in a randomized double-blind placebo-controlled clinical trial.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mazandaran University of Medical Sciences
• Treatments: Memantine

Criteria

Inclusion Criteria:

• Presentation at first 24hrs of disease onset

• Confirmation of ischemic stroke in MCA territory by imaging.

• Accepted consent form

Exclusion Criteria:

• Allergy history to memantine

• Stage 4 -5 renal failure base on Acute Kidney Injury Network criteria

• Moderate to severe hepatic failure (Child-Pugh criteria, grade B and C)

• History of epilepsy

• History of dementia

• History of memantine use in recent 6 months

• Pregnancy or breastfeeding

• Severe drug adverse effects