Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT)
Status:
Not yet recruiting
Trial end date:
2024-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to determine if fluoxetine increases lysosomal stress
in patients with recurrent IDHwt glioma by evaluating LAMP1 expression in tumor samples
obtained pre-resection via biopsy and during surgery. Lysosomes are organelles (structures in
cells) that contain digestive enzymes (substances that break down chemicals) that help keep
the cells free of extra or worn out cell parts. Fluoxetine, a drug approved by the FDA to
treat problems like depression and anxiety, can cause changes to structures in cells called
lysosomes that then improve how well the chemotherapy drug temozolomide (TMZ) kills cancer
cells in the brain.