Evaluation of Emerging New Treatments for Infection Prevention in Total Joint Replacement
Status:
Not yet recruiting
Trial end date:
2024-10-01
Target enrollment:
Participant gender:
Summary
At the end of total joint replacement (TJR) surgery, surgeons wash and clean the surgical
wound. This is done to lower the risk of infections. Currently, most surgeons use saline to
wash the surgical wound and do not place antibiotics in the wound . However, some recent
studies have shown that using povidone-iodine and chlorhexidine-based solutions (both are
types of antiseptics) to wash the surgical site and placing antibiotics directly into the
wound may be effective in reducing infections in TJR surgery compared to saline and no
antibiotics. However, no study has determined which solution is better at reducing the number
of infections in patients undergoing TJR. The investigators also do not know if the addition
of antibiotics applied to the wound will decrease infections. Currently, there are no
surgical guidelines around infection prevention in total joint replacement. A large scale,
multi-site, pragmatic 3 x 2 factorial randomized controlled trial is need that compares these
six treatment groups. However, before this, a smaller pilot study must be conducted to
determine the feasibility of a larger study. PREVENT-iT will address these important gaps in
knowledge and clinical practice.