Evaluation of Co-Administration of Betahistine as Adjunctive to Olanzapine in Healthy Subjects
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
The study aims to evaluate the safety and pharmacokinetics of extended release and standard
formulations of betahistine when administered as monotherapy and as compared to their safety
and pharmacokinetics when co-administered with olanzapine and to determine potential dose
limiting toxicities and/or drug-drug interactions affecting the pharmacokinetics or safety of
either medication, with particular emphasis on somnolence and weight gain secondary to
olanzapine treatment