The use of phenytoin metabolism to produce S-HPPH accounts for more than 85% of its
metabolism. This metabolic pathway is mediated by the activity of CYP2C9.
The purpose of the present study is:
1. To confirm the use of phenytoin metabolic ratio as a marker of CYP2C9 activity
2. To correlate phenytoin metabolic ratio with CYP2C9 genotype
3. To study the frequency distribution of CYP2C9 activity in-vivo
Phase:
N/A
Details
Lead Sponsor:
Hadassah Medical Organization
Collaborator:
United States - Israel Binational Science Foundation