Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis
Status:
Completed
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
Toxoplasmosis affects one to two newborn each 10000 births. Among them, 1 to 2 % develop
learning disabilities or die, and 4 to 27 % develop a chorioretinitis sometimes leading to an
amblyopia responsible for visual impairment. Toxoplasmosis uveitis affects too adults
immunocompetent and immunodepressed who have had an acquired toxoplasmosis. Clinical
diagnosis of ocular toxoplasmosis is more complicated in presence of posterior
neuro-retinitis, inflammation of the papilla, uveitis without chorioretinitis, fuchs
heterochromic iridocyclitis, scleritis, diffuse necrotizing or multifocal retinitis. In this
situation biological markers diagnostic and prognostic of toxoplasmosis uveitis are useful.
Highly kept molecules (during evolution) like stress proteins (Hsp) are are found in the host
and the pathogen and there can trigger a crossed immune response. Stress proteins haven't
been explored yet, in the context of toxoplasmosis uveitis on humans.
The hypothesis is that Hsp70 and antibodies anti-Hsp70 are diagnostic and prognostic markers
of ocular toxoplasmosis.
The goal is to evaluate diagnosis value of biological markers (Hsp70 and antibodies IgG
anti-Hsp70) in toxoplasmosis uveitis.