Evaluation of Automated Propofol Delivery in Patients Undergoing Thoracic Surgery
Status:
Completed
Trial end date:
2019-06-25
Target enrollment:
Participant gender:
Summary
Automated delivery of propofol using computer-controlled closed loop anaesthesia device
delivers propofol based on patient's frontal cortex electrical activity as determined by
bi-spectral index (BIS). Evaluation of anaesthesia delivery by these systems has shown that
they deliver propofol and maintain depth of anaesthesia with far more precision as compared
to manual administration.
By automatically controlling anaesthesia depth consistency they provide time to the
anaesthesiologist to focus on other aspects of patient care such as managing intra-operative
hemodynamics and ventilation perturbations during major surgeries.
Closed loop anaesthesia delivery system (CLADS) is an indigenously developed continuous
automated intravenous infusion system which delivers propofol based on patients EEG profile
(BIS) feedback. Although a few studies have already evaluated these automated systems in
patients undergoing thoracic surgery, but suffered from significant limitations (small number
of patients, not dedicated to thoracic surgery cohort). Currently, there is no data available
regarding CLADS performance vis a vis adequacy of GA and haemodynamic profile in patients
undergoing thoracic surgery.
We contend that propofol as delivered by CLADS will proffer greater consistency to
anaesthesia depth, intra-operative hemodynamic stability, and rapid recovery upon anaesthesia
discontinuation than manual means of delivering propofol TIVA. This randomised controlled
study aims to compare the efficiency of CLADS-driven propofol TIVA versus manually controlled
propofol TIVA in patients undergoing thoracic surgery.