Evaluation of Atorvastatin Treatment on Carotid Plaque.

• Status: Terminated
• Trial end date: 2007-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate the effect of 18 months treatment with atorvastatin 80mg or atorvastatin 10mg on the carotid vessel plaque morphology, in particular, the effect on evident necrotic lipid rich core of the plaque in patients.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pfizer; Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• Subjects with measurable carotid plaque with lipid and are eligible for statin therapy.

Exclusion Criteria:

• Subjects at higher risk for cardiovascular disease with a screen LDL-cholesterol greater than 120 mg/dL,

• Subjects currently on high dose statin, and

• Subjects with contraindications for MRI or statin therapy.