Evaluation of Amphotericin B in Optisol-GS for Prevention of Post-Keratoplasty Fungal Infections.
Status:
Withdrawn
Trial end date:
2019-07-03
Target enrollment:
Participant gender:
Summary
With the increasing popularity of endothelial keratoplasty, a coincident increase in the rate
of fungal infections post-keratoplasty has been seen in the United States. In this study, the
eye bank will harvest pairs of donor corneas and randomize one cornea from each pair to be
stored in Optisol-GS per Eye Bank Association of America guidelines. The eye bank will add
amphotericin B 0.255 μg/mL (antifungal) to the storage solution for the mate cornea. The
study donor corneas will be assigned to participants who are scheduled to undergo Descemet
membrane endothelial keratoplasty. The surgeons, participants, and evaluators will remain
masked regarding the donor cornea storage solution assignment. The participants will be
followed for 6 months.