Objective
To evaluate the phenotypic characteristics and diagnoses in a large cohort of 304 consecutive
girls referred due to tall stature. Furthermore, to evaluate the effect of oral
administration of 17β-estradiol on predicted adult height in constitutionally tall statured
girls.
Design
A single-centre retrospective observational study of 304 girls evaluated due to tall stature
between 1993 and 2013.
Setting
Tertiary referral centre for pediatric endocrinology.
Participants
A total of 304 girls were evaluated for tall stature of whom 39 (13%) were excluded due to
missing data, reclassification, overgrowth syndromes or associated comorbidities. Another 58
(19%) girls did not fulfil auxological criteria for constitutionally tall stature (CTS),
resulting in a total of 207 (68%) girls eligible for analysis.
Main Outcome Measures
The effect of oral treatment with 17β-estradiol on height, predicted adult height (PAH),
final height and circulating hormones in constitutional tall statured girls.