Evaluation Study of New Compounds With Potential Use in Schizophrenia

• Status: Not yet recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Different compounds that might modify the glucose regulation in the central nervous system will be evaluated in healthy volunteers. Several examinations will be performed in order to get a detailed plan how these substances might work.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Central Institute of Mental Health, Mannheim
• Collaborator: Max-Planck Institute for Metabolism Research
• Treatments: Cannabidiol; Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Healthy volunteers

• Informed consent given by the subject

• Both, female and male subjects may participate

• Age between 18 and 65 years

• Negative drug-screening at the time of screening

• In female participants in fertile age, reliable contraception, which means contraception's pearl-index is equal or smaller than 1.

• Non-Smoker

• Body Mass Index between 18 and 40.

Exclusion Criteria:

• Lack of accountability

• Any current psychiatric disorder through the Structured Clinical Interview for DSM-IV (SCID) at the time of screening

• Any known psychiatric or neurological illness in the participant's history.

• Known family history concerning psychiatric disorders

• Relevant use of cannabis (which is defined on the present state of knowledge as at the most five times lifetime-consumption and no consumption for at least one year)

• Pregnancy or lactation phase in female at the time of screening

• Severe physical (internal) or neurological illness, especially cardiovascular, renal, advanced respiratory, haematological or endocrinological failures or infectious diseases (acute hepatitis A, B or C or HIV) assessed at the time of the screening by the subject's history, clinical examination and laboratory testing, at the discretion of the investigator

• Consumption of any illegal drugs (except cannabis in history, see above)