Overview

Evaluating the Use of Prednisone to Decrease Pegylated Interferon Beta-1a Side Effects

Status:
Unknown status
Trial end date:
2020-05-31
Target enrollment:
0
Participant gender:
All
Summary
Some of the most common side effects of the multiple sclerosis drug Plegridy (pegylated interferon beta-1a) include flu-like symptoms and injection site reactions. Physicians often advise patients to take Tylenol or aspirin prior to injection, but in this study the investigators evaluated whether using a low dose of oral steroid in combination with Tylenol reduced flu-like symptoms and injection site reactions.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Holy Name Medical Center, Inc.
Collaborator:
Biogen
Treatments:
Acetaminophen
Interferon beta-1a
Interferon-beta
Interferons
Prednisone
Criteria
Inclusion Criteria:

- diagnosed any form of MS (relapsing remitting, primary progressive, secondary
progressive), any EDSS (expanded stability status scale) score

Exclusion Criteria:

- prior allergic reaction to interferon products, congestive heart failure, elevated
liver enzymes