Evaluating the Use of Fibrin Tissue Adhesive in Melanoma Patients
Status:
Completed
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
Primary Objective:
1. To determine whether the use of a fibrin sealant applied to superficial groin soft tissues
following node dissection can result in decreased cumulative postoperative drainage, earlier
drain removal, and lower incidence of seroma.
Secondary Objectives:
1. To determine the postoperative morbidity rate using fibrin sealant following superficial
groin dissection.
2. To assess patient-valuation of outcome by performing a cost-benefit analysis using a
willingness-to-pay model.
3. To determine if serum levels, lymphatic fluids level, or cutaneous expression of
vascular endothelial growth factor-D (VEGF-D), vascular endothelial growth factor-C
(VEGF-C) or their receptor, vascular endothelial growth factor receptor-3 (VEGFR-3)
correlates with nodal tumor burden or development of lymphedema in patients with
melanoma.