Evaluating the Roles of Estrogen and Progesterone in Heart Metabolism
Status:
Terminated
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
Estrogen and progesterone are two main female sex hormones. When a woman goes through
menopause, the body's production of estrogen and progesterone significantly decreases. Recent
studies have shown that the breakdown of fatty acids in cardiac muscle is important in
maintaining a healthy heart, and that estrogen may enhance this process. Also, cardiovascular
disease (CVD) occurs more frequently in postmenopausal women than in premenopausal women.
This study will determine in postmenopausal women whether estrogen increases the heart's
ability to use fats as energy and whether progesterone decreases this effect.
Phase:
N/A
Details
Lead Sponsor:
Washington University School of Medicine
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI) Robert Wood Johnson Foundation