Evaluating the Efficacy of Atezolizumab in Advanced Non-small Cell Lung Cancer (NSCLC)
Status:
Recruiting
Trial end date:
2025-10-01
Target enrollment:
Participant gender:
Summary
This is a phase II clinical trial aimed at evaluating the efficacy of PD-L1 inhibition with
atezolizumab in advanced squamous and non-squamous NSCLC patients previously treated with
anti-PD-1 therapy with either nivolumab or pembrolizumab.
In order to account for the variability of response kinetics to PD-1 directed therapy,
patients will be enrolled in 3 parallel cohorts based on the best overall response to PD-1
directed therapy.
- Cohort 1 (progressive disease)
- Cohort 2 (stable disease with minimum 12 weeks of therapy)
- Cohort 3 (partial to complete response followed by progressive disease)