Uremic pruritus remains one of the most frustrating and potentially disabling symptoms in
patients with end stage renal disease. It affect up to 90 percent of patients with end stage
renal disease. Several hypotheses have been postulated for the possible underlying etiology,
but none is conclusive. Aside from kidney transplantation, which is only definitive
treatment, therapeutic approaches have largely been empirical, and no firm evident-base
treatments are available. The main goal of therapy remains to minimize severity of pruritus.
In Iranian traditional medicine Cassia senna L. is used for healing uremic pruritus . In this
study investigators considered to evaluate effect of Cassia senna L. in uremic pruritus by a
double blind placebo control clinical trial. It is hypothesized that oral Cassia senna L. may
attenuate uremic pruritus by decreasing serum IL-2, IFN-γ and TNF-α.