Evaluating the Effect of Cromolyn Sodium in Uremic Pruritus
Status:
Completed
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
Pruritus is a major disorder among the skin derangements in advanced renal failure. Recent
information suggests that interactions between dermal mast cells and distal ends of
nonmyelinated C fibers may be important in the precipitation and regulation of the sensory
stimuli.Patients having uremic pruritus have been noted to have increased levels of plasma
histamine and tryptase as well as increased numbers of dermal mast cells.Cromolyn sodium is a
mast cell stabilizing agent that inhibits degranulation of mast cells and the release of
histamine, tryptase, and leukotrienes. It is hypothesized that oral cromolyn sodium may
attenuate uremic pruritus by decreasing serum tryptase level.