Evaluating a Potential Pharmacokinetic Kratom-oxycodone Interaction Concurrent With Clinical Endpoints
Status:
Not yet recruiting
Trial end date:
2025-05-01
Target enrollment:
Participant gender:
Summary
The goal of this study is to investigate whether the botanical product kratom affects how the
body processes the opioid drug oxycodone. The main research questions to be answered are
two-fold:
1. How does kratom affect the manner in which oxycodone is metabolized (broken down and
removed) by the body?
2. Does kratom change the effects oxycodone exerts on the body?
Healthy adult participants will complete four study arms, during which they will be given the
following:
- Kratom (as a tea)
- A single dose of oxycodone (as a tablet)
- Kratom tea and a single dose of oxycodone
- Kratom tea for four days, then kratom tea and a single dose of oxycodone
Phase:
Early Phase 1
Details
Lead Sponsor:
Washington State University
Collaborator:
National Center for Complementary and Integrative Health (NCCIH)