Evaluating Suzetrigine for Pain Control Following TKA
Status:
NOT_YET_RECRUITING
Trial end date:
2026-08-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine works to treat pain after total knee replacement surgery in adults. It will also learn about the safety of suzetrigine. The main questions it aims to answer are:
Does suzetrigine lower the amount of opioid pain medicine participants use after surgery?
Does suzetrigine have any effect on postoperative patient-reported outcomes, including pain scores, range of motion, length of stay, and KOOS/PROMIS surveys?
Researchers will compare suzetrigine to a placebo to see if suzetrigine works to treat pain after total knee replacement surgery.
Participants will:
Take suzetrigine or a placebo by mouth for 14 days after surgery
Receive standard pain care, including opioid pain medicine only if needed
Report their pain levels using short daily surveys
Attend routine follow-up visits after surgery