Evaluating Lip Repositioning for the Treatment of Excess Gingival Display With and Without Pretreatment With Botox

• Status: Not yet recruiting
• Trial end date: 2022-09-20
• Target enrollment: 0
• Participant gender: All

Summary

Since the introduction of the lip repositioning procedure by a number of modifications to the technique have been introduced. All these modifications were made to prevent the main complication of lip repositioning surgeries 'relapse'. Relapse was found to occur in 8% of the cases treated .

Botox injections have been suggested as a possible treatment for cases with relapse Botox acts by blocking muscular activity, however, Botulinum toxin technique has a transitory effect (6-7 months). . By combining Botox as a pretreatment and lip repositioning surgery, Botox injections maybe a useful adjunct in improving and stabilizing the results of achieved, by paralyzing the muscles during the healing period.

There are no studies, to the investigator's knowledge, exploring the use of botox combined with lip repositioning to decrease muscle pull and therefore decrease the relapse.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: abobotulinumtoxinA; Botulinum Toxins, Type A

Criteria

Inclusion Criteria:

1. Gummy smile more than 3mm.

2. Adults >18 years.

3. Non-smokers.

4. Patients with healthy systemic condition

5. Normal clinical crown dimensions.

6. Good oral hygiene.

Exclusion Criteria:

1. Natural dentition upper anterior

2. Pregnant or lactating women.

3. Patients with inflamed gingiva or gingival enlargement.

4. Inflammation or infection at the site of injection.

5. Patients with allergy to botulinum toxin, lactose, and albumin.

6. Concurrent use of aminoglycoside antibiotic that enhances the action of the toxin. (Jaspers, Pijpe, & Jansma, 2011)

7. < 3 mm attached gingivae that might create difficulties in flap design, stabilization and suturing.

8. Patients using anticholinesterase or other agents interfering with neuromuscular transmission