Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital

• Status: Unknown status
• Trial end date: 2020-06-30
• Target enrollment: 0
• Participant gender: All

Summary

interventional randomized clinical trial will be done at Assuit University Hospital ( Chest Department and Caridothoracic surgery department ),and all patients presented with complex septate pleural effusion in whom the symptoms excepted to be relieved by pleural fluid drainage will be included in our study within the two next years.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Mesna; Streptokinase

Criteria

Inclusion Criteria:

• Patients with symptomatic pleural effusion in whom the symptoms excepted to be relieved by pleural fluid drainage.

• Presence of intrapleural adhesions as documented sonographically.

• Difficult thoracentesis.

• Failure of satisfactory pleural fluid drainage 24 hours following intercostal tube (ICT) placement provided that the tube was properly positioned and not obstructed.

• Written consent, free and informed.

Exclusion Criteria: patients have contraindications for any of our procedures will be excluded.

• Contraindications for streptokinase instillation i.e. (Previous allergic reaction, bronchopleural fistula, trauma or surgery within 48 hrs, history of hemorrhagic stroke, coagulation defects and previous streptokinase thrombolysis).

• Patients who are unfit for general anaesthesia.