Evaluate the Muscle Protection Effect of Sevoflurane Sedation in Vascular Surgery
Status:
Completed
Trial end date:
2018-10-19
Target enrollment:
Participant gender:
Summary
Halogenated anaesthetic agents (HAA) may induce protective processes by pre-conditioning the
myocardium. All of the literature shows that HAA induce pre-conditioning, thanks to a class
effect, and Sevoflurane is the most widely used today.
In humans, the protective effects of halogenated agents have principally been studied in
heart surgery and have shown encouraging clinical results. It seems that HAA induce both
pre-conditioning of the myocardium (early and late) and post conditioning.
Given these protective effects of HAA, in 2007, the American Heart Association (AHA)
recommended the use of HAA for anaesthesia maintenance in non-cardiac surgery in patients
with a high cardio-vascular risk. The aim of this study is to show a decrease in
rhabdomyolysis and tissue distress (kidneys, myocardium and liver), thanks to Sevoflurane
anaesthesia, in the post-operative period following vascular surgery with clamping